Scintigraphy ofthe salivary glands in sjogens syndrome. Twenty minutes after the injection, vitamin c chewable tablet was given to stimulate the secretion and continued until the end of the study period 40min. The mean age of the group was 61 years ranging from 16 to 81 years. The mean age of the group was 61 years ranging from 16 to. Dysfunctional salivary glandular secretion seemed to be associated with abnormal morphology of the papillae of the tongue. We studied a cohort of 101 patients with suspected ss seen at a single centre in brittany, france.
Sjogrens syndrome diagnosis and treatment mayo clinic. Its usefulness to evaluate salivary function after rad iotherapy has been demon strated in patients with head and neck malignan cies 9. Pdf uptake of 99mtcpertechnetate in salivary glands reflects intact salivary gland parenchyma. Gastric emptying scintigraphylower gastrointestinal motility scintigraphyliverspleen imaginggastrointestinal bleed imagingmeckels diverticulum imaginghemangioma studyesophageal transit studyperitoneovenous shunt patencysalivary gland imaging14c urea breath testing continuing education credit information voice technologists. However, its role as an independent investigative procedure in the evaluation of salivary gland dysfunction requires a study with a larger sample size, may yield a statistical significant result and it can also act as an adjunct along with. Protocols by system page 6 department of radiology. This page was last edited on september 2019, at 07. Nm workflow for creating teaching file cases revised 8152019 then click save and view case b click on add to folder at upper right, and select nuclear medicine cases to be certified attending name the attending is the one who originally read the case. Evaluation of quality of life related to i1 therapy in. Evaluation of salivary gland dysfunction using salivary gland. These glands include the parotid and submandibular glands, located on both sides of the neck just below the ears and under the jaw. Your doctor might also do a lip biopsy to detect the presence of clusters of inflammatory cells, which can indicate sjogrens syndrome. Salivary scintigraphy is a gauge of the salivary flow rates and can provide a good measurement of salivary gland dysfunction. Protocol for salivary gland scintigraphy after venous puncture in a superficial vein of the arm, dynamic salivary gland scintigraphy was obtained immediately after intravenous administration of 370 mbq of 99 mtcpertechnetate.
Protocols by system page 6 department of radiology uw. Salivary gland scintigraphy and noncontrast enhanced neck ct were performed before the initial rit in all patients. Additionally, an abnormal salivary gland scintigraphy result is accepted by the americaneuropean consensus group as a criterion for the diagnosis of sjogrens syndrome. In such cases, the functional status of a gland can be assessed using scintigraphy. However, the finding of low flow rates is not specific to ss references saito t, fukuda h, horikawa m, et al. Scintigraphy is highly sensitive for lesion detection and provides a functional display of skeletal metabolism. The photopeak was centred at 140kev with a 20% window. Salivary gland ultrasonography improves the diagnostic. Improved quantification of salivary gland scintigraphy by. Scintigraphysalivary gland scintigraphy uses tc99m pertechnetate which helps in assessment of salivary gland dysfunction in disorders like sjogrens syndrome.
Scintigraphy for gastrointestinal bleeding was first described in 1977 with the use of tc99m sulfur colloid. Dynamic sgs dsgs can provide valuable information on the function and morphology of salivary glands and has been used for more than 40 years, for ss and various other salivary glands pathologies 1518. It emphasises the functional salivary impairment, whichis ofgreat importance in theearly stages ofsalivary gland disease. Quizlet flashcards, activities and games help you improve your grades. Salivary scintigraphy employing radionuclides has proved to be an accurate, reproducible method for demonstrating salivary gland involvement in sjogrens syndrome.
Introduction and overviewhepatobiliary imaginggastric emptying scintigraphylower gastrointestinal motility scintigraphyliverspleen imaginggastrointestinal bleed imagingmeckels diverticulum imaginghemangioma studyesophageal transit studyperitoneovenous shunt patencysalivary gland imaging14c urea breath testing. The aim of the study was to evaluate the salivary gland dysfunction in a patient with uncontrolled type 2 diabetes using salivary gland scintigraphy. In this study the automatic separation of oral and salivary gland activity and spontaneous secretion by means of factor analysis for quantitative salivary gland scintigraphy is introduced. A salivary gland scan uses a special camera and a tracer radioactive chemical to take pictures of the salivary glands. The role of salivary gland scintigraphy in the evaluation of salivary gland dysfunction in uncontrolled type ii diabetic patients b senthilkumar 1, s sathasivasubramanian 2 1 department of oral medicine and radiology, k. In this study the authors explore the role of selenium in preservation of salivary glands function after. Salivary gland dysfunction after radioactive iodine i1 therapy in patients following total. A normal scintiscan is unlikely to miss significant pathology as demonstrated by sialography, but sialography must always be performed if there is a. Scintigraphy of the major salivary glands could therefore form part of the routine investigation of patients with sjogens syndrome. Quantitative analysis of 99m tcpertechnetate salivary gland scintigraphy has been used in the evaluation of salivary gland function, but so far no one method can be considered optimal for this task. The key roles of scintigraphy in osteoporosis, osteomalacia, hyperthyroidism, paget disease, and primary hyperthyroidism are discussed. The knowledge of the findings in different imaging modalities about sjogren syndrome in salivary glands it is important to suspect it. Sialagogue administered to evaluate secretory capacity. Pdf assessment of salivary gland function using salivary.
It is distributed in accordance with the creative commons attribution non commercial cc bync 4. During the initial part of the study, scintigraphy was done using a semiquantitative methodology, precluding accurate quantification of salivary function. Salivary gland dysfunction in systemic lupus erythematosus. Of the few tests currently available for investigation of salivary gland function, sodium pertechnetate scintigraphy is a noninvasive one. It is suggested that scintigraphy could become the initial screening procedure in the assessment of salivary gland disease. Approach to diagnosis of salivary gland disease from nuclear. Salivary gland function scan parotid scintigraphy a salivary gland scan is a nuclear medicine test that evaluates the function of the salivary glands. The average time interval from pretreatment salivary gland scintigraphy and ct to the initial rit was 8 days range, 115 days. Scintigraphy of the salivary glands in sjogens syndrome ncbi. Changes in the salivary glands after rit were evaluated on the scintigraphy and ct scans obtained. Blood flow was measured and uptake and excretion were verified. Of the nine patients included in this study, five with proven unilateral parotitis initially had diffuse high uptake of99mtcpertechnetate in the affected glands with adequate washout following vitamin c stimulation. If we can do early diagnosis we will save money, time y often pain in others procedures.
After intravenous administration of 99mtc sodium pertechnetate, dynamic scintigraphy was performed. It can be a suitable alternative to salivary flowrate measurements for quantification of postradiotherapy salivary. To differentiate malignant from benign salivary tumors, or to evaluate salivary gland function after radiotherapy. Salivary gland scintigraphya suitable substitute for. In this paper we report both on a validated acquisition protocol and a normal database for standardized quantitative salivary gland scintigraphy.
Gastrointestinal scintigraphy involves the intravenous, oral, transcatheter to include enteric tubes, or intraperitoneal administration of a radiopharmaceutical that transits or localizes in the salivary glands, gastrointestinal tract, or peritoneal cavity, followed by gamma camera imaging, with or without computer acquisition. The aim of this study was to evaluate whether salivary gland ultrasonography sgus improves the diagnostic performance of the 2012 acr classification criteria for ss. The role of salivary gland scintigraphy in the evaluation of. Prospective longitudinal assessment of parotid gland function. The role of salivary gland scintigraphy in the evaluation. Any information contained in this pdf file is automatically generated from digital material. Jun 17, 2015 objectivesymptoms of salivary gland dysfunction frequently develop after radioactive iodine rai therapy, but have generally not been correlated with assessment of salivary gland functioning. In numerous studies, dsgs protocols and parameters of saliva accumulation and. The salivary glands where it is concentrated and secreted into the saliva. Objectivesymptoms of salivary gland dysfunction frequently develop after radioactive iodine rai therapy, but have generally not been correlated with assessment of salivary gland functioning. Assessment of salivary gland function using salivary scintigraphy in pre and post radioactive iodine therapy in diagnosed thyroid carcinoma patients article pdf available february 2016 with. The aim of this study was to determine whether there was a correlation between salivary symptoms and salivary functioning as assessed by salivary scan parameters.
Salivary gland scintigraphy sgs is a non invasive method of salivary gland function assessment. Salivary gland scan my health alberta government of alberta. All structured data from the file and property namespaces is available under the creative commons cc0 license. As a result of these tests, no patients in this study were found to be suffering from sjogrenssyndrome. The diagnostic impact of quantitative salivary gland scintigraphy is. Sequential salivary scintigraphy, or the visual recording with a gamma scintillation camera of the uptake, concentration, and excretion of 99m tc pertechnetate by the major salivary glands after the administration of sodium pertechnetate tc 99m, was performed on 20 female patients with sjogrens syndrome. A prospective study was undertaken of 24 consecutive patients bearing a diagnosis of systemic lupus erythematosus sle, 78 consecutive patients bearing a diagnosis of classic or. Baishideng publishing group inc, 7041 koll center parkway, suite 160, pleasanton, ca 94566, usa. Scintigraphy of the salivary glands in sjogens syndrome. Salivary scintigraphy has been useful for investigation of multiple. Iv injection of technetium 99m pertechnetate concentrated in and excreated by glandular structures salivary, thyroid,mammary. Salivary gland imaging diagnostic imaging of salivary gland disease may be undertaken to differentiate inflammatory processes from neoplastic disease, distinguish diffuse disease from focal suppurative disease, identify and localize sialoliths, and demonstrate ductal morphology.
In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was. Evaluation of the concordance of sialometry and salivary. The salivary gland scintigraphy was performed, with radioactivity measured at 1st, 20th, and 40th minutes. Pdf scoring analysis of salivary gland scintigraphy in patients with. The parotid, submandibular, and sublingual glands are called the major.
The diagnosis of salivary gland disease relies mainly on the clinical presentation and in certain conditions on more specialized investigations. After intravenous administration of 99mtc sodium pertechnetate, dynamic. Assessment of salivary gland function in sjogrens syndrome. Infrequently performed studies in nuclear medicine. Sequential salivary scintigraphy sss is a dynamic anatomicfunctional radionuclide study inwhich the uptake, concentration, and excretion ofradiopertechnetate by the major salivary glands are studied with agamma camera. Of four patients with proven warthins tumor, two had focal high uptake in the parotid masses and two had diffuse high uptake on baseline images. Selenium may protect salivary glands from radioactive. After intravenous injection of 10 mci tc99m sulfur colloid, it is rapidly extracted from the blood 3minute halflife by reticuloendothelial cells of the liver, spleen, and bone marrow. When altered, any of these tests fulfill the criterion,14. Full text get a printable copy pdf file of the complete article 647k, or click on a page image below to browse page by page. Files are available under licenses specified on their description page. Salivary gland imaging techniques for the diagnosis of sjogrens.
Pdf scoring analysis of salivary gland scintigraphy in. The normal range of the salivary glandular secretory ratio s. Scoring analysis of salivary gland scintigraphy in patients with sjogrens syndrome article pdf available in annals of nuclear medicine 178. Salivary gland scintigraphy plays a significant role in the evaluation of salivary gland dysfunction. Evaluation of diagnostic parameters from parotid and.
Aimthus, the concordance between results of sialometry and salivary glands scintigraphy was evaluated. Patient should not have been given ki or perchlorate within 48 hours preceding the scan. Scintigraphy nuclear medicine, pet functional study of salivary glands. The clinical and technical aspects of each study, along with a brief comparison of alternative modalities that may also be used, are discussed. Radioactive iodine and the salivary glands pdf radioactive iodine 1i targets the thyroid gland and has been. R institute of dental science and research, trichengode, namakkal district, tamil nadu, india 2 department of oral medicine and radiology, sri ramachandra dental college.
Evaluation of salivary gland dysfunction using salivary. Selenium is a known antioxidant that has shown to decrease side effects of radiation therapy in other cancers. Dec 07, 2017 to differentiate malignant from benign salivary tumors, or to evaluate salivary gland function after radiotherapy. Summary scintigraphy of the salivary glands with technetiumsodium pertechnetate 99mtc was undertaken on 320 patients with oral dryness or connective. Frontiers salivary function after radioiodine therapy.
The role of salivary gland scintigraphy in detection of. The diagnostic value of salivary gland scintigraphy in patients suspected of having primary sjogrens syndrome ss was studied in 149 consecutive patients who presented with joint andor muscle complaints in combination with dryness of the mouth andor eyes and in 20 control subjects. Regarding the use of ct and mri techniques in diagnosing ss, conflicting results have been reported in literature. This nuclear medicine test involves the injection into a vein of a radioactive isotope, which is tracked over an hour to see how quickly it arrives in all your salivary glands. Salivary gland scintigraphy is indicated when the ori. The close correlation between clinical manarrago, rain, brocheriou, rocher ifestations and scintigraphy indicates that salivary imagingis asuitable. Salivary gland damage is a known complication of radioactive iodine therapy.
You can now navigate to the appropriate attendings folder. However, no direct comparison of the sgs findings of ss patients and thyroid cancer patients postrai has been performed using the same sgs protocol. Pdf the purpose of the present study was to evaluate the validity of a scoring system based on excretion rate of salivary gland scintigraphy in. In the present study, we devised and validated a patient basis scoring system based on excretion rate of salivary gland scintigraphy, and compared the total. Salivary gland imaging and sialochemistry radiological and biochemistry 1. The results were compared with those of other procedures currently used to evaluate.
Assessment of salivary gland function in patients after. Oct 16, 2015 scintigraphy nuclear medicine, pet functional study of salivary glands. Three patients arereported whohad obstruction of stensens ducts which was documented by both sss and contrast. Pdf quantitative salivary gland scintigraphy researchgate. This mechanism has been used to perform salivary scintigraphy in the evaluation of a variety of salivary gland disor ders i,12j. The xerostomia appeared to be detectable by the above method. Prospective longitudinal assessment of parotid gland. Moreover, salivary gland scintigraphy is easy to perform, reproducible and welltolerated by the patient.
Among them, both the sialometry1517 and the scintigraphy18,19 assess the gland function, not only its image. In the present study, sgs was performed in ss patients and in thyroid cancer patients postrai, and scintigraphic parameters were compared. Salivary gland scintigraphy sgs provides an objective means of diagnosing salivary gland dysfunction in sjogrens syndrome ss patients and in thyroid cancer patients after radioactive iodine rai therapy. Selenium may protect salivary glands from radioactive iodine. Salivary gland scintigraphy with 99mtcpertechnetate in. Introduction in general, differentiated thyroid carcinoma dtc is a condition less frequent in children or adolescents than in adults, ranging from 0. This technique is easy to perform, reproducible and well tolerated by patients. Assessment of salivary gland dysfunction after radioiodine. Scoring analysis of salivary gland scintigraphy in patients with. Dynamic salivary gland scintigraphy using 99m tcpertechnate is a simple, reproducible, and minimally invasive test that provides quantitative estimates of parenchymal and excretory function of individual major salivary glands. This study is performed on neonates, infants, and children to determine if there is evidence of pulmonary aspiration of saliva that might explain recurrent pneumonias. A normal scintiscan is unlikely to miss significant pathology as demonstrated by sialography, but sialography must always be performed if there is a suspicion of duct obstruction on scintigraphy. Scintigraphy from latin scintilla, spark, also known as a gamma scan, is a diagnostic test in nuclear medicine, where radioisotopes attached to drugs that travel to a specific organ or tissue radiopharmaceuticals are taken internally and the emitted gamma radiation is captured by external detectors gamma cameras to form twodimensional images in a similar process to the capture of x.
Salivary gland scintigraphy sgs using tc99m pertechnetate has been widely used to evaluate salivary gland dysfunction in ss patients 57 and in thyroid cancer patients postrai 4, 8. Unfortunately, we still not have an effective treatment to protect salivary glands from the radiation. It also provides a rapid evaluation of the total skeleton but, the appearances are nonspecific. Salivary gland scintigraphy salivary gland scintigraphy was performed after intravenous administration of 185mbq of 99mtcp using a dual head gamma camera with a parallelhole, lowenergy, highresolution collimator siemens e. In this study, a semiquantitative method providing 2 functional parameters for objective assessment of salivary gland function by scintillation camera imaging was tested. All patients underwent salivary gland scintigraphy using 99m tcpertechnate prior to initiation of definitive chemoradiotherapy. Salivary gland imaging and sialochemistry radiological. Quantitative salivary gland scintigraphy recently has been standardized 3943.
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